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The focus is shifting from the question of whether classical biomagnification occurs (for which evidence is limited) to the more nuanced question of how the chronic ingestion of ENMs affects the long-term health, fitness, and reproductive success of higher-trophic-level organisms.124,126,163 Impact of multi-stage environmental aging: as this review has stressed, ENMs are subject to continuous transformation

The inflammasome is a complex of multiprotein signaling pathways that includes NLRP1, NLRP3, AIM2, and NLRC4, which orchestrate host defense mechanisms against infections and physiological disturbances 29

This binding mechanism, a bit like a lock (epitope) and key (paratope), or two puzzle pieces with the same unique pattern, enables them to interlock together

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