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That position on the list places the actual peptide concentration somewhere between 0.001 and 0.1 percent by weight, with no encapsulation, no pH protection, and no delivery system that addresses any of the four failure modes above

J Clin Endocrinol Metab 82(4):1007-1013 Greenstein J, Guest S, Tan JC, Tummala P, Busque C, Rabkin R (2006) Circulating growth hormone binding protein levels and mononuclear cell growth hormone receptor expression in uremia

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In hereditary cancers, heterozygous mutations are usually accompanied by trisomy of the whole chromosome 7, suggesting that when only a single allele is mutated the mutation must be present in multiple copies to produce the full transformed phenotype [Schmidt et al