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Most of the binding events observed at this site involve aromatic rings and the residues Asp334, Phe343 and Lys345

The subsequent combinatory use of molecules implicated in GH secretion through inhibition of the somatostatinergic tone, such as arginine (ARG), or the synthesis of receptor-orphan pharmaceutical compounds capable of stimulating pituitary somatotrophs to release GH, such as the GH secretagogues (GHSs), improved the reproducibility of GH response to GHRH alone, thus gaining access into the clinical practice by means of different diagnostic approaches

[PMC free article: PMC6230679] [PubMed: 30455701] [CrossRef] 13

The prevalence of this disease is high and increasing, currently impacting approximately 25% of the adult population in the United States [16]