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Several specific factors contribute to why your throat hurts from smoking: Heat exposure from smoke damages the mucous membranes Chemical irritants in smoke trigger inflammatory responses Dehydration of throat tissues from hot, dry smoke Coughing reflexes further irritate already inflamed tissues According to research on throat discomfort after smoking, the temperature of smoke can reach levels that cause immediate irritation to the pharynx and larynx, resulting in that characteristic burning sensation

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1 2 "MINSAP Resolucin No.275" [MINSAP Resolution No.275] (PDF)