fsp1 is a glutathione-independent ferroptosis suppressor. suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury Unleashing Ferroptosis in Human Cancers:

As GPX4 is entirely dependent on GSH to neutralize toxic lipid peroxides, the depletion of GSH directly weakens the cell's most critical line of defense against ferroptosis (105)

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The unique domains of coronavirus nsp13, such as the zinc-binding domain, the stalk and the 1B domain, are all important for helicase activity 122

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