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Pure peptide aggregation appears as uniform cloudiness or fine particulates suspended evenly throughout the solution, with no colour shift or smell

Its tolerability profile supports its use in patients with altered bowel motility, though we have no objective data confirming benefit in CIRS

That means starting with a low dose and gradually increasing it over several weeks

On the other hand, our 2-piece d-monobody synthesis strategy has the advantage that the C-terminal peptide contains the FG loop and the randomized library residues of the C/D strands, both major contributors to monobody-target binding, whereas the N-terminal peptide only contains that CD loop, which often is not involved in target binding