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Proteomic studies have identified multiple E3 ligases that target SIRT1, including MDM2 (under oxidative stress-induced cell senescence) 42 , SMURF2 (to inhibit proliferation and tumor formation) 43 , CUL4 (to promote autophagy) 44 , and COP1 (to exacerbate lipid toxicity) 45

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For transparency: this figure does not come from any published human study the actual mouse research used subcutaneous injection at 20 mg/kg three times daily, a very different route, species, and dosing basis than the oral use commonly sold