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It typically begins with declining blood levels (stage I), followed by low cellular levels (stage II), increased homocysteine levels and reduced DNA synthesis (stage III), and finally macrocytic anemia (stage IV)

The mercapturic acid of acrolein, OPMA, was shown to be more toxic than its homolog, S -(4-oxobutyl)- N -acetylcysteine, in human lung adenoma A549 cells [68]

Figure 3 As a first step to investigating this question, we mined two Arabidopsis cat2 microarray datasets for genes encoding the enzymes listed in Supplemental Table 1

A Polymorphism in the Gene Encoding Heat Shock Factor 1 (HSF1) Increases the Risk of Type 2 Diabetes: A Pilot Study Supports a Role for Impaired Protein Folding in Disease Pathogenesis