selenium is part of the glutathione peroxidase enzyme system and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications 9.4: Selenium - Medicine LibreTexts

The evidence combined BPC 157 with the time-dependently activated VEGFR2-Akt-eNOS signaling pathway, the increase in endothelial tube formation (chick chorioallantoic membrane (CAM)) (both suppressed by Dynasore, an endocytosis inhibitor), the increased expression and internalization of VEGFR2, and essential acceleration of blood flow recovery and vessel number to rescue hind limb ischemia in rats with a completely excised femoral artery [94]

doi: 10.1016/j.addr.2022.114422, 47

Protects Against Chemotherapy Side Effects Reduces nerve damage, fatigue, and organ toxicity

Disadvantages are poor stability, high production cost, and high production difficulty