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doi: 10.3389/fnagi.2022.830569, 129 WangY.XuY.ZhuC

In addition, bystanders, including those with specificity for viral pathogens, typically lack expression of canonical exhausted markers (e.g., PD-1, CD39, and CXCL13) and exhibit low tumor reactivity signatures [146, 148, 149]

PTPN2 is oxidized and inactivated by H 2 O 2 and the expression levels of PTPN2 are increased in GBM and isocitrate dehydrogenase (IDH) wild-type gliomas