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Besides, bypassing first-pass metabolism through non-oral routessuch as transdermal, sublingual, intranasal, or injectable formulationscan significantly improve systemic availability 30

doi:10.1016/S0021-9258(19)52465-6

In this study, SBA-15 mesoporous silica nanoparticles (SBA-15 MSN) with a potent fluorescence emission were synthesized by a sol-gel method for targeted drug delivery