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Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Various therapeutic approaches require different microbial strains, depending on their ability to thrive in the body

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The development of more potent GlyT1 inhibitors was initially inspired by structural modifications of sarcosine, particularly through the introduction of bulky hydrophobic substituents at the nitrogen atom, an approach guided by emerging structural and pharmacological insights into GlyT1 and its relationship to other members of the SLC6 transporter family