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Cellular decision making and biological noise: From microbes to mammals

in an immunosuppressed person, or in a Se-deficient population), the more viral copies will be generated per unit time, which, applying the multiplier from the basal mutation rate, leads to an increased pool of mutants because of the larger viral population size, thus providing further opportunity for selection of a more fit viral strain (Reference Moya, Elena and Bracho15,Reference Domingo16)