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As you get older, the systems that rely on NAD+ (like energy production, cognitive function, skin repair, immune health, and inflammation regulation) start to slow down, and declining NAD+ levels appear to be a key driver behind that slowdown

They reach fat-metabolism research questions from opposite directions

On top of that, any NAD+ that your cells do have left gets used up faster in response to stress, illness, or environmental damage

Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk