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These cytokines reach the brain and affect regions implicated in mood, motivation, and energy, contributing to symptoms such as fatigue, persistent sadness, irritability, and reduced motivation

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In agreement with earlier research, our findings demonstrated that abemaciclib triggers the endoplasmic reticulum (ER) stress response, modifies the mitochondrial membrane potential, and consequently causes loss of membrane integrity, cytochrome c release, ROS generation, cellular endogenous antioxidant depletion, caspase activation, pro-apoptogenic proteins BAX and P53 upregulation, and anti-apoptogenic protein Bcl-2 downregulation

Follow-up endoscopy performed 7 days later showed the presence of a 2 cm-sized newly developed mucosa necrosis at the lesser curvature of the pyloric channel, which was caused by ischemic necrosis of the gastric mucosa after HS-E injection