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Melatonin, 5-hydroxytryptophan, some derivatives of the TRP-KYN pathway (e.g., KYN, 3-HKYN, and ANA), and the TRP-IND pathway, particularly IPA, can cross the BBB

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease

Moreover, evidence documented that riboflavin supplementation had the same therapeutic effects on patients with migraines, as compared with the common medications (35, 36)