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Tanshinone is one of its active ingredients, and in vitro studies have shown that it significantly reduces the formation of free radicals and lipid peroxidation induced by gentamicin, reduces the increase in hearing threshold induced by kanamycin in a dose-dependent manner, and reduces HCs loss

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The impact of curcumin on these enzymes that modify DNA and histones could depend not only on the concentration of this bioactive phytochemical, it is also important to take into account the cell model used