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ChiE displaying inhibitory activity on all three pathways clearly protects susceptible spirochetes from complement-mediated killing comparable to ChiB, ChiC, and ChiD, however, the ChiE-producing strain was killed by human serum (Fig

Due to decreased saliva production, patients have trouble eating, speaking, and swallowing 1, 2

These changes may also promote programmed cell death in activated fibroblasts and other pro-fibrotic cells, thereby reducing fibrogenic activity

This review aims to systematically explore the dual mechanisms of iron deficiency in tumors, its specific effects in different tumor types, its impact on tumor metabolism, immune responses, and therapy, and its prospects as a potential therapeutic target