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If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended.[12][15] Several laboratory tests should be performed prior to treatment with cyanocobalamin, including serum vitamin B12, folate, iron, hematocrit, and reticulocyte count

Since mitochondria synthesize and degrade proteins independently, the question arises whether the availability of free amino acids affects protein turnover in mitochondria and how it influences the balance between mitochondrial and cytosolic proteins

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