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(3) Additional use: Pyridostigmine is also used as prophylaxis against organophosphate nerve agents (e.g., soman) in military settings

Thus, APE showed significant cytotoxicity toward both PBMCs and PMNs compared to the control group, with PBMCs being more sensitive to APE (Fig

149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages