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Unlike isotretinoin, tretinoin is not usually associated with severe systemic side effects, making it a more accessible treatment option, although prescription strength tretinoin is still regulated by medical guidelines

This interesting finding shows that PAP is a potent toxic agent but also its biotransformation leads to formation of additional, toxic, conjugated products capable of damaging the kidney cells

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Liposomal glutathone formulations (GSH encapsulated in phospholipid vesicles) are more stable than non-liposomal forms because the lipid bilayer shields the GSH molecule from oxidative exposure