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2 These disorders arise from mutations in either mitochondrial DNA (mtDNA) or nuclear DNA (nDNA), both of which encode subunits of OXPHOS as well as structural or functional mitochondrial proteins

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For example, in BALB/c mice bearing CT26 tumors, two-dimensional risedronate-manganese nanobelts (RMn-NBs) combined with RT were shown to promote ICD, with significant increases in ICD markers such as CRT, HMGB1, ATP, and IFN- [222] (Fig