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Pharmacological ablation of astrocytes disrupts the ability of orexin neurons to respond to glucose concentration changes, as orexin neurons rely on astrocyte - derived lactate

If those pieces are ignored, even a well-chosen inhaled therapy may underperform or feel harder to tolerate

And a recent research shown that DNA polymerase gamma deficiency induced mtROS increasing which promotes RICTOR expression to trigger pro-survival autophagy [74]