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In parallel, in an immunodeficient context, patient-derived xenograft models make important links to the clinic by facilitating the study of DTP heterogeneity of individual patients, including patient-specific disease states 43,178

The antioxidant effects of curcumin can reduce oxygen radicals produced in vivo , induce antiapoptotic effects, and resist myocardial infarction-induced cardiac dysfunction (Lv et al., 2016)

Resveratrol increased the rhythmicity of Sirt1 leading to the restoration of circadian expression of lipogenesis and clock-related genes such as Acc1 , Fas , Ppar and Srebp-1c