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In contrast, GSSG did not reproduce this effect, indicating that the antioxidant and/or structural features of GSH are essential to promote elevations in cytoplasmic calcium levels (Shaw et al., 1996)

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While the ability to proliferate and migrate uncontrollably is characteristic of tumor cells, glutamate has been shown to serve as a growth factor and signaling medium in certain types of tumor tissues in both an autocrine and paracrine manner (17)

Since viral replication necessitates pyrimidine nucleotides derived from de novo synthesis to fulfill its nucleic acid demands, inhibiting DHODH activity can effectively impede the biosynthesis of viral DNA and RNA, thereby suppressing viral replication