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5.3 Biomaterial topography regulates osteogenic differentiation strategies 5.3.1 Matrix stiffness In order to better create a microenvironment suitable for cell growth, natural proteins or synthetic polymers meet the demand through changes in composition, concentration, and synthesis steps

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Moreover, the activation of multiple mechanisms associated with MAP kinases leads to the activation of the NFB transcription factor and induces an inflammatory reaction [22, 54]