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doi: 10.1093/ndt/gfy175

Activation of MC4R inhibits the activity of orexigenic neurons and stimulates the activity of anorexigenic neurons, ultimately leading to a decrease in food intake (37)

On the other hand, another study showed that NRF2 knockdown in human CAR-T cells enhanced anti-tumor immunity in a xenograft murine model implanted with a B-lymphoblastoid cell line, showing that eliminating the antioxidant effect may be beneficial in a lymphoma setting (124)

Red blood cell defects can lead to increased production of free radicals, which damage cellular membranes and disrupt their function, promoting increased destruction and impaired production of red blood cells (Fibach 2008)