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ROS-induced HIF-1 stabilisation leads to the activation of macrophages in the early stages of wound healing, and promotes metabolic reprogramming towards glycolysis 75,76 , as well as increased angiogenesis 76

There were no significant differences between the two cuprizone groups (p = 0.9017)

NAFLD has become increasingly common in the UK, affecting approximately one in three adults, often associated with obesity, type 2 diabetes, and metabolic syndrome

Thus, reducing Hsp90 acetylation through overexpression of AAV gene-delivered HDAC isozyme (HDAC6) can increase Hsp90-eNOS interaction and restore eNOS-derived NO production, thereby ameliorating LSEC dysfunction and liver inflammation