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For sertraline for anxiety , some patients may require higher doses, up to 200mg daily, for optimal symptom management

Physiol Rev 88(4):12431276 Presley TD, Morgan AR, Bechtold E, Clodfelter W, Dove RW, Jennings JM, Kraft RA, King SB, Laurienti PJ, Rejeski WJ, Burdette JH (2011) Acute effect of a high nitrate diet on brain perfusion in older adults