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PGE2 is produced in response to dectin-1 recognition of -glucan and both PGE2 and PGE2EP4 have been shown to stimulate dendritic cell production of IL-23, in turn activating Th17 lymphocytes and potentially other IL-23Rexpressing cell types

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If binding of one IGF1 molecule to the IGF1R dimer is sufficient for receptor activation, then both the WT:WT and WT:F701A dimers are expected to be active, and the IGF1R activity in cells transfected with WT and F701A plasmids will be 75% of that in cells transfected with the WT plasmid alone