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and the lack of examination of the thiol network in an animal model expressing an E3 ligase-incompetent mutant of human parkin [3, 45, 50, 55]

Under physiological conditions of oxidative stress, p53 functions predominantly as an antioxidant, protecting cells against oxidative damage

Importantly, it remains to be determined if these changes in SWI/SNF complex composition are a consequence of the neuroendocrine differentiation or have a key function in driving de-differentiation to AR-negative prostate cancer