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The binding-induced conformational changes may facilitate the activation of G-proteins, which are signaling proteins hypothesized to be found on the intracellular side of the GHRH receptor

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In addition, the peptide was designed to selectively stimulate GH production in the anterior pituitary without affecting the production of other hormones, such as prolactin and ACTH, which are commonly triggered by other, less selective GHSs [8]

Studies in growth hormone-deficient mice show that while other growth hormone secretagogues increased body fat through growth hormone-independent mechanisms that included increased feeding, ipamorelin's effects on body composition are primarily mediated through its growth hormone-releasing properties