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277 ZhangZ.ZhangY.YuwenT.HuoJ.ZhengE.ZhangW.et al (2022)

2015), rescued the LD biogenesis defects caused by ORP5 depletion (Supp

They secrete pro-inflammatory mediators and elastase, which induce chondrocyte apoptosis and extracellular matrix (ECM) degradation, thereby promoting the progression of OA ( On one hand, similar to macrophages and other immune cells, neutrophils can secrete interleukin-1 (IL-1), which exacerbates cartilage damage in OA through multiple pathways

1 Introduction Multiple myeloma (MM), a hematologic malignancy characterized by clonal proliferation of bone marrow plasma cells, manifests clinically through CRAB criteria: hypercalcemia, renal dysfunction, anemia, and osteolytic lesions ( Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Zhang et al., 2022