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Preclinical studies in the published literature have examined GHK-Cu in the context of fibroblast culture, gene-expression profiling, collagen-related enzyme activity assays, and dermal extracellular-matrix models

Journal of pharmaceutical and biomedical analysis, 2008, 47(3): 596- 602

For multi-level involvement, the systemic effects of TB-500 become even more valuable, as it supports healing throughout the body rather than at a single site