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However, as mentioned above, even D1KO/D2KO mice are able to maintain normal levels of serum T3 (60), pointing towards a major role for the thyroid gland in serum T3 production as well

The induction (or inhibition) of hepatic and intestinal drug-metabolizing enzymes, specifically cytochrome P450 (CYP) and/or drug transporters like P-glycoprotein, as well as pharmacokinetic interactions, which have been more thoroughly studied, maybe the cause of the altered drug concentrations caused by co-administration of herbs (147)

10.1016/j.plantsci.2011.04.004 Plant Sci

Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds Chem