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Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models

The reduction in visceral fat was sustained over the study period, but the fat tended to return to baseline levels upon discontinuation of the therapy, indicating the need for ongoing treatment to maintain these benefits