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Professor of Medicine Boston University School of Medicine Copyright 2001-2026 Linus Pauling Institute Figure Alternative Text Figure 1

Together with Cu, the mentioned element is a part of Cu,Zn-superoxide dismutase 30 belonging to a family of enzymes that catalyze the dismutation of the superoxide radicals 31

The enrichment of differentially expressed genes in the mTOR pathway in connection with sterol regulatory elements binding proteins ( Figures 3A, C ) is also interesting and in line with recent reports showing that the mTOR-driven metabolic reprogramming of macrophages increased flux through the mevalonate pathway and this process is involved in trained immunity (57)