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Sulforaphane (a glucosinolate compound found in some cruciferous vegetables like broccoli) is one of the most commonly cited natural Nrf2 activators, though there are many others shown to have similar effects on Nrf2-induced enzymatic activities and metabolites

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Other copper peptides studied include DAHK (the N-terminal copper-binding domain of human serum albumin), which has high copper affinity but primarily serves a copper transport rather than signaling function