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It is noteworthy that serum ferritin is an acute-phase protein, and its level may be influenced by factors such as infection, inflammation, and tumors

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Consequently, bisphosphoglycerate phosphatase activity is favored over the kinase activity and leads to the depletion of 2,3-diphosphoglycerate (2,3-DPG), which in turn negatively impacts oxygen binding and off-loading kinetics 13,14