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Description

Fox Foundation

The optimized formulation was intranasally administered in rats with rotenone-induced PD animal model, motor function and coordination were investigated besides testing the levels of different biomarkers and histopathological examination

Non-volatile compounds Preclinical studies In vitro studies such as establishing cell culture models, assessing cellular viability and apoptosis, as well as investigating the modulation of signaling pathways, are preliminary steps for the in vivo studies that represent animal models of PD, including toxin-induced models (e.g., rotenone) and genetic models (e.g., SNCA transgenic mice)