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Therapeutic targets Studies have confirmed that glycolysis accelerates the metabolic switch associated with increased lactate production in tumor cells as a result of the increased expression of oncogenes, mainly c-Myc and HIF-1 286

These genes code for a group of cytoprotective and antioxidant proteins that include multiple components of the thioredoxin pathway, antioxidant enzymes, i.e., NADPH quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), and numerous enzymes that regulate glutathione biosynthesis and utilization (80)

However, the longer-term KDp regimen appeared to have a greater protective impact, and a more impressive reduction of CCR2 content in AAA tissue

Planta 211 , 246255 (2000)