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In the work devoted to the development of a base editing system and its verification on the model of tyrosinemia I with FAH protein deficiency, the incorporation of 5moU into ABE mRNA and guide RNA resulted in stable protein expression in HEK293T cells and increased editing efficiency compared to unmodified mRNA [292]

3.2.1 Dominant model The TT + CT genotype showed significant heterogeneity compared with the CC genotype in the dominant genetic model (I 2 = 69.9%

Ensuite, la dose peut tre administre tous les 3-4 jours pendant 2-3 semaines ou jusqu' une rmission complte

Twenty-five patients were enrolled and injected with 4 ml of autologous platelet rich plasma under fluoroscopic guidance via transforaminal epidural injection into area of affected nerve root