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NF-B not only induces canonical pro-inflammatory cytokines (TNF-, IL-6, pro-IL-1) but simultaneously up-regulates facilitative glucose transporter, metabolically locking macrophages, DCs and activated T cells into a glycolytic, NO-rich phenotype that fuels chronic mucosal inflammation (110112)

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Because dopaminergic signaling exerts considerable influence over intestinal function, constipation is a common problem in Parkinson's disease