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In vitro study demonstrated that SIRT1 attenuates degeneration of DNs by increasing expression of FOXO3a and hypoxia-inducible factor 1 alpha (HIF-1) with inhibition of oxidative stress (Rodriguez et al

Its primary function is to disrupt the interaction between FOXO4 and the tumor suppressor protein p53, leading to the selective apoptosis of senescent cells and a deceleration of biological aging

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