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doi: 10.1073/pnas.97.20.10723

How to Increase Glutathione Levels Naturally If you have an MTHFR mutation or a SNP on the GSTM1 gene, you dont detoxify heavy metals as well or process glutathione as efficiently as most people

10.1186/s12974-017-1004-5 79 NeherJ

Mitochondrial alterations subsequent to chemotherapy include a reduction in mitochondrial biogenesis, altered mitochondrial dynamics, mitophagy defects, increase of H 2 O 2 production, and increased initiation of apoptosis