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1) are largely based on the WCRF/AICR systematic reviews and Continuous Update Project reports, with additional evidence from systematic reviews and large pooled analyses published since the most recent WCRF/AICR reports

For the peptide, peptide analog and antibody based pharmaceutical compositions, the general range for the initial immunization (for either prophylactic or therapeutic applications) will be from about lOOg to about 1 g of polypeptide for a 70 kg patient, followed by boosting dosages of from about 1 g to about 1 gm of polypeptide pursuant to a boosting regimen over weeks to months, depending upon the patient's response and condition, e.g., by measuring the level of parasite or antibodies in the patient's blood

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These alterations can impact electrophysiological activity and neural network function, contributing to behavioral symptoms