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Using perfused murine livers to dissociate cells, isolated hepatocytes stained with pericentral (CD73 or glutamine synthetase) and periportal (E-cadherin) were categorized into periportal or pericentral zones based on their positive cell populations for certain zonated markers ( in vivo functional relevance can be difficult to infer from gene and protein expression only

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Research has demonstrated increased levels of markers of ferroptosis, such as 4-HNE, in individuals with ALS