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One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF

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It can further be measured quantitatively as 50% lethal dose (LD50) values

After equilibration was reached, N -ethylmaleimide (NEM, final concentration 40 mM) or iodoacetamide (final concentration 50 mM) were added and a second measurement loop was started