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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrrioxamine (Desferoxamine) in rat liver homogenates

k cat and K m values could not be obtained due to the low activity of the mutant enzymes