Iron absorption and metabolism are illustrated in Figure 2
Playing sports with other humans, where you react to a moving object or opponent, trains brain mitochondria that power reaction time and coordination Male gymnasts and pole vaulters live about eight years longer than their general population, while cyclists gain about two years, and sumo wrestlers lose about ten Cyclists are super fit cardio-wise, but this result suggests VO2 max alone is not the whole key to longevity Gymnasts tend to be short, pole vaulters tall, so it is probably not height, and both have strong upper bodies, wild coordination, and lots of time flipping and hanging He guesses that whole-body functional movement and being upside down a lot may help stuff like immune function, cancer risk, and neurological health more than we realize The relative proportions and how stretched out and what is the quality of your joint tissue probably has a lot of severely underappreciated causation in terms of cancer and autoimmune disease. Spending real time upside down is probably uniquely good for the circulation of body fluids He started testing his own weaknesses: a bit of jiu jitsu and boxing made him realize his foot coordination was off, and rolling made him dizzy, so he added one forward and backward roll to his daily morning routine He swapped some overhead presses for wall handstand pushup work and is slowly working toward full handstand pushups to be more gymnastic in his training The point is not to become a pro gymnast, it is more like: figure out which basic movement patterns you actually suck at and plug them into your week instead of only doing what you are already good at You always want to be pushing yourself to new achievements, but then you also want to structure things so that you dont lose the ones that you did. Injuries, concussions, and the hidden tax on your body Fighters and athletes rack up injuries like broken hands, ribs, knees, and surgeries, and each one pulls mitochondrial resources away from general maintenance into emergency repair If your goal is a long, healthy life or even max strength, injury prevention should be priority number one, not something you bolt on at the end People love to say they are back to 100% after injuries, but in reality, they are 100% with a permanent tax from that trauma, and many are not even truly fully repaired MMA guys get knocked out, come back too fast, and get knocked out again because both the brain and the whole body are still compromised Theres no way that healing from a brain injury is not taking a toll systemically
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The reason these results are important is that niclosamide is currently being considered, formulated, and in some cases tested in clinical trials in a range of formulations, including a micronized niclosamide in spray dried lysozyme (37, 38, 77, 78)
